威尼斯论坛555503|首頁(歡迎您)

何春江

访问次数:发布日期:2020-09-29

何春江 博士、教授、博导 

che@whu.edu.cn;che@mail.hzau.edu.cn

 

教育经历:

1999.9-2003.6 武汉大学生命科学学院 生物技术 学士

2003.9-2008.6 武汉大学生命科学学院 细胞生物学 博士


工作经历与任职:

2009.2-2012.4 芝加哥大学医学院血液与肿瘤部 博士后 导师:陈建军

2012.5-2013.12 斯坦福大学医学院心血管研究所 博士后 导师: Joseph Wu

2014.1-2020.9 武汉大学基础医学院  副教授

2020.10至今 华中农业大学威尼斯论坛555503|首頁(歡迎您) 教授


研究方向:

1.白血病细胞命运决定:利用单细胞测序和组学大数据,结合生物信息学和实验验证,研究白血病细胞的演化和命运决定机制。

2.RNA代谢和白血病:通过分子、细胞和动物模型等实验手段,研究RNA剪切和非编码RNA在白血病发生发展中的调控机制和功能。


代表论文(通讯*,一作#)

1. Dong X#, Chen K#, Chen W#, Wang J, Chang L, Deng J, Wei L, Han L*, Huang C*, He C*. circRIP: an accurate tool for identifying circRNA-RBP interactions. Briefings in Bioinformatics. 2022 Jun 1:bbac186.


2. Li J#, Chen K#, Dong X#, Xu Y, Sun Q, Wang H, Chen Z, Liu C, Liu R, Yang Z, Mei X, Zhang R, Chang L, Tian Z, Chen J, Liang K*, He C*, Luo M*. YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation. Cell Proliferation. 2022 Jan;55(1):e13157.


3. Feng J#, Chen W#, Dong X#, Wang J, Mei X, Deng J, Yang S, Zhuo C, Huang X, Shao L, Zhang R, Guo J, Ma R, Liu J, Li F, Wu Y*, Han L*, He C*. CSCD 2.0: An integrated interactional database of cancer-specific circular RNA, Nucleic Acids Research. 2021 Sep 22:gkab830.


4. Liu X#, Chen W#, Fang Y#, Yang S, Chang L, Chen X, Ye H, Tang X, Zhong S, Zhang W, Dong Z*, Han L*, He C*. ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues. Briefings in Bioinformatics. 2021 Jul 13:bbab274.


5. Shao L#, Jiang G#, Yang X, Zeng M, Cheng J, Kong S, Dong X, Chen T, Han S, Yin J, Liu W, He X, He C*, Peng B*. Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy. FASEB J. 2021 Feb.


6. Xu X#, Zhang J#, Tian Y#, Gao Y#, Dong X, Chen W, Yuan X, Yin W, Xu J, Chen K*, He C*, Wei L*. CircRNA inhibits DNA damage repair by interacting with host gene. Molecular Cancer. 2020 Aug 24;19(1):128. doi: 10.1186/s12943-020-01246-x.


7. Xiao S#, Cao S#, Huang Q#, Xia L#, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M*, He C*, Xia L*. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4


8. Feng J*#, Chen K#, Dong X#, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C*. Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0.


9. Han Y#, Feng J#, Xia L#, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L*, He C*. CVm6A: A Visualization and Exploration Database for m6As in Cell Lines. Cells. 2019 Feb 17; 8(2). pii: E168. doi: 10.3390/cells8020168.


10. Feng J#, Xiang Y#, Xia S#, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C*, Han L*. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2018 Nov 27. doi: 10.1093/bib/bbx070.


11. Lei L#, Xia S#, Liu D#, Li X#, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L*, He C*. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2018 Jun 20. doi: 10.1093/bib/bbx007.


12. Xia S#, Feng J#, Chen K#, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L*, He C*. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863. ESI高被引


13. Xia S#, Feng J#, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L*, He C*. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081. ESI高被引


14. He C*#, Hu H#, Wilson KD#, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC*. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Apr. pii: CIRCGENETICS.115.001264.


15. Li Z#, Herold T#, He C#, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Döhner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J*. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.


16. He C#, Li Z#, Chen P#, Huang H, Hurst LD*, Chen J*. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.


17. Mi S#, Li Z#, Chen P#, He C#, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD*, Chen J*. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas.0914900107.


18. He C#, Zhou F, Zuo Z, Cheng H*, Zhou R*. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.0004732.  


19. He C#, Cheng H*, Zhou R*. GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny. Journal of Biosciences. 2007 Dec;32(7):1273-80.


20. He C#, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H*, Zhou R*. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.


研究资助:

1.国家自然科学面上项目circ-AFF2调控PRC2复合物介导的AML发生发展机制研究 2019.1- 2022. 12 主持

2.国家自然科学青年基金LncRNA-LINC01268通过激活HDAC2促进急性髓性白血病增殖的分子机制研究 2016.1-2018.12 主持

3.国家科技重大专项 艾滋病和病毒性肝炎等重大传染病防治(子课题) 基于大数据分析的风险评估和预警预测 2018.1-2020.12 参与

4.湖北省自然科学青年基金 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12  主持

5.中央高校自主科研青年项目 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持

6.中央高校自主科研交叉项目 癌症特异环状RNA剪切数据库的构建 2018.1.-2019.12 主持


学术兼职及获奖:

中国微循环协会肿瘤专业委员会委员
武汉生理学会理事
美国血液学学会(ASH)会员
中国生理学会血液生理学专业委员会会员
Genes, Frontiers in Oncology 等杂志客座编辑
武汉大学珞珈青年学者(2014)
武汉大学朱裕璧医学奖(2014)
湖北省自然科学技术进步奖二等奖 (2021)


承担课程:

病理生理学


研究生招生:

实验室招收具有较强分子细胞生物学实验背景(实验方向)或者有较强编程经验(生信方向)的同学报考博士或硕士研究生


 

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