威尼斯论坛555503|首頁(歡迎您)

金红林

访问次数:发布日期:2021-04-21

金红林 博士、教授、博导


教育经历:

2007/09-2012/06,华中科技大学,生物化学与分子生物学,博士

2005/09-2007/06,华中科技大学,生物化工,硕士

2001/09-2005/06,湖北工业大学,生物工程,本科


工作经历与任职:

2021/04-至今,华中农业大学,威尼斯论坛555503|首頁(歡迎您),教授

2014/07-2021/04,华中科技大学,武汉协和医院肿瘤中心,讲师/副研究员/研究员

2012/04-2014/06,华中科技大学,武汉光电国家实验室,博士后

2008/05-2011/01,多伦多大学/安大略癌症研究院,Medical Biophysics,访问学者


研究方向:

肿瘤免疫治疗新技术、新靶点,以及相关免疫机制研究注重学科交叉融合和临床转化。

1、免疫细胞调控/重塑新靶点和新机制;

2、放射衍生物和肿瘤免疫治疗:通过研究经典的放射生物学效应,对放疗产物进行鉴定分析,一方面探索放疗免疫增效新机制,另一方面建立系列“间接放疗新技术”;

3、通过设计系列抗肿瘤载体平台策略,克服肿瘤免疫抑制性微环境,提高T细胞在肿瘤微环境中的活性,构建个体化肿瘤疫苗。


代表性论文

1. Yushuai Liu#, Yuanyuan Geng#, Beilei Yue, Pui-Chi Lo, Jing Huang*, Honglin Jin*. Injectable Hydrogel as A Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment. Frontiers in Immunology. 2022.

2. Zhan Tuo#, Qianyuan He#, Zhanjie Zhang# , Haojie Liu, Jie Zhou, Yan Hu, Yajie Sun, Chao WanZushun Xu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Irradiation conditioning of adjuvanted, autologous cancer cell membrane nanoparticle vaccines. Chemical Engineering Journal. 2022. Doi.org/10.1016/j.cej.2021.134437

3. Yuhan Zhou, Lisen Lu, Yan Hu, Jingshu Meng, Yanan Gao, Huaduan Zi, Qianyuan He, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Jing Chen*. Hypochlorous acid oxidation-modified anti-tumor drug enhances immunogenicity and inhibits melanoma optimized by an injectable hydrogel. Bioactive Materials. 2022. 9, 541-553.

4. Chao Wan#, Yajie Sun#, Yan Hu#, Jing Huang#, Lisen Lu, Jingshu Meng, Yanan Gao, Huaduan Zi, Qianyuan He, Jonathan F. Lovell, Kunyu Yang*, Honglin Jin*. Radiated tumor cell secretions loaded peptide hydrogel for immunotherapy to advanced cancer. Nano Today. 2021. 41 (2021): 101323.

5. Jingshu Meng#, Yan Li#, Chao Wan#, Yajie Sun, Xiaomeng Dai, Jing Huang, Yan Hu, Yanan Gao, Jonathan F. Lovell, Gang Wu, Honglin Jin*, and Kunyu Yang*. Targeted senescence-like cancer-associated fibroblasts increases non-small cell lung cancer radiosensitivity and ameliorates radiation-induced pulmonary fibrosis. JCI Insight. 2021. 6(23): e146334.

6. Yajie Sun#, Yan Hu#, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. Local biomaterials-assisted immunotherapy for effusions in the pleural and peritoneal cavities caused by malignancies. Biomaterials Science. 2021, 9, 6381-6390.

7. Lisen Lu#, Yajie Sun#, Chao Wan, Yan Hu, Pui-Chi Lo, Kunyu Yang*, Honglin Jin*. Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. Current Opinion in Biotechnology. 2021. 69. 153-161.

8. Jie Zhou#, Chao Wan#, Jing Cheng, Hao Huang*, Jonathan F. Lovell, Honglin Jin*. Delivery strategies for melittin-based cancer therapy. ACS Applied Materials & Interfaces. 2021. 13, 15, 1715817173

9. Yanan Gao#, You Qin#, Chao Wan, Yajie Sun, Jingshu Meng, Yan Hu, Jing Huang, Honglin Jin*, Kunyu Yang*. Small extracellular vesicles: a novel avenue for cancer management. Frontiers in Oncology. 2021.11 : 441

10. Yajie Sun, Xiangru Feng, Chao Wan, Jonathan F. Lovell, Honglin Jin*, Jianxun Ding*. Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy. Asian Journal of Pharmaceutical Sciences. 2021. 6.12 : 129-132

11. Chao Wan#, Yajie Sun#, Yu Tian#, Lisen Lu, Xiaomeng Dai, Jingshu Meng, Jing Huang, Qianyuan He, LingLing Zhang, Jonathan F. Lovell, Gang Wu, Honglin Jin*, Kunyu Yang*. Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming. Science Advances. 2020; 6 : eaay9789.

12. Xiaomeng Dai#, Lisen Lu#, Suke Deng, Jingshu Meng, Chao Wan, Jing Huang, Yajie Sun, Yan Hu, Bian Wu, Gang Wu, Jonathan F. Lovell, Honglin Jin*, Kunyu Yang*. USP7 targeting modulates antitumor immune response by reprogramming tumor-associated macrophages in lung cancer. Theranostics. 2020; 10(20):9332-9347.

13. Xiaomeng Dai#, Jingshu Meng#, Suke Deng#, Lingling Zhang, Chao Wan, Lisen Lu, Jing Huang, Yan Hu, Zhanjie Zhang, Jonathan F. Lovell, Gang Wu, Kunyu Yang*, Honglin Jin*. Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel. Theranostics. 2020; 10(7):3049-3063.  

14. Qianyuan He#, Zhanjie Zhang#, Haojie Liu, Zhan Tuo, Jie Zhou, Yan Hu, Yajie Sun, Chao WanZushun Xu, Jonathan F. Lovell, Desheng Hu*, Kunyu Yang*, Honglin Jin*. Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery. Nanoscale. 2020. 12, 14788-14800.

15. Boyang Sun#, Jing Huang#, Moustafa T. Mabrouk, Yumiao Zhang, Honglin Jin*, Jonathan F Lovell*. A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology. 2020.

16. Haojie Liu#, Yan Hu#, Yajie Sun#, Chao Wan, Zhanjie Zhang, Xiaomeng Dai, Zihan Lin, Qianyuan He, Zhe Yang, Piao Huang, Yuxuan Xiong, Jinguo Cao, Xu Chen, Qi Chen, Jonathan F. Lovell, Zushun Xu*, Honglin Jin* and Kunyu Yang*. Co-delivery of bee venom melittin and a photosensitizer with an organicinorganic hybrid nanocarrier for photodynamic therapy and immunotherapy. ACS Nano. 2019, 13(11), 12638-12652.

17. Dyego Miranda#, Chao Wan#, Hailey I Kilian, Moustafa T. Mabrouk, Yuhan Zhou, Honglin Jin*, Jonathan F Lovell*. Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomater. Sci., 2019,7, 3158-3164.  

18. Honglin Jin#, Chao Wan#, Zhenwei Zou#, Guifang Zhao, LingLing Zhang, Yuanyuan Geng, Tong Chen, Ai Huang, Fagang Jiang, Jue-Ping Feng, Jonathan F. Lovell, Jing Chen*, Gang Wu*, and Kunyu Yang*. Tumor Ablation and Therapeutic Immunity Induction by an Injectable Peptide Hydrogel. ACS Nano. 2018, 12 (4), 3295–3310.

19. Yanwu Chu, Feng Chen, Yun Tang, Tong Chen, Yunxin Yu, Honglin Jin*, Lianbo Guo*, Yongfeng Lu, and Xiaoyan Zeng. Diagnosis of nasopharyngeal carcinoma from serum samples using hyperspectral imaging combined with a chemometric method. Optics Express. 2018, 26 (22), 28661-28671.

20. Yanwu Chu#, Tong Chen#, Feng Chen, shisong Tang, Yun Tang, Honglin Jin*, Lianbo Guo*, YongFeng Lu, and Xiaoyan Zeng. Discrimination of nasopharyngeal carcinoma serum using laser-induced breakdown spectroscopy combined with an extreme learning machine and random forest method. Journal of Analytical Atomic Spectrometry. 2018, 33, 2083-2088.

21. Yibiao Zou#, Honglin Jin#, Fei Sun, Xiaomeng Dai, Zushun Xu, Sheng-li Yang, Guangfu Liao. Design and Synthesis of Lead Sulfide-Based Nanotheranostic Agent for Computer Tomography/Magnetic Resonance Dual-Mode Bioimaging Guided Photothermal Therapy. ACS Appl. Nano Mater. 2018, 1 (5), 2294–2305.

22. Honglin Jin#, Guifang Zhao#, Jianli Hu#, Quanguang Ren, Kui Yang, Chao Wan, Ai Huang, Pindong Li, Jue-Ping Feng, Jing Chen*, and Zhenwei Zou*. Melittin-Containing Hybrid Peptide Hydrogels for Enhanced Photothermal Therapy of Glioblastoma. ACS Applied Materials & Interfaces, 2017; 9(31): 25755-25766.

23. Honglin Jin, Yuan Qian, Yanfeng Dai, Sha Qiao, Yuan Qian, Chuan Huang, Jing Chen*, Zhihong Zhang*. Magnetic Enrichment of Dendritic Cell Vaccine in Lymph Node with Fluorescent-Magnetic Nanoparticles Enhanced Cancer Immunotherapy. Theranostics, 2016; 6(11): 2000-2014.

24. Yuan Qian#, Honglin Jin#, Sha Qiao, Yanfeng Dai, Chuan Huang, Lisen Lu, Qingming Luo*, Zhihong Zhang*. Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy. Biomaterials. 2016, 98: 171-83.

25. Ying Zheng#, Yanyan Liu#, Honglin Jin#, Shaotao Pan, Yuan Qian, Chuan Huang, Yixin Zeng, Qingming Luo, Musheng Zeng*, Zhihong Zhang*. Scavenger Receptor B1 is a Potential Biomarker of Human Nasopharyngeal Carcinoma and Its Growth is Inhibited by HDL-mimetic Nanoparticles. Theranostics, 2013, 3(7): 477-486.

26. Honglin Jin, Jonathan F Lovell, Juan Chen, Qiaoya Lin, Lili Ding, Kenneth K. Ng, Muthiah Manoharan, Zhihong Zhang*, Gang Zheng*. Mechanistic insights into LDL nanoparticle-mediated siRNA delivery. Bioconjugate Chemistry. 2012, 23(1): 33-41.

27. Haiming Luo#, Jiyun Shi#, Honglin Jin#, Di Fan, Lisen Lu, Fan Wang*, Zhihong Zhang*. An 125I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials. 2012, 33(19): 4843-4850.

28. Mi Yang#, Honglin Jin#, Juan Chen, Lili Ding, Kenneth K. Ng, Qiaoya Lin, Jonathan F. Lovell, Zhihong Zhang, Gang Zheng. Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticle. Small. 2011, 7(5):568-573.

29. Honglin Jin, Juan Chen, Jonathan F, Lovell, Zhihong Zhang*, Gang Zheng*. Synthesis and development of Lipoprotein-based nanocarriers for light-activated theranostic. Israel Journal of Chemistry. 2012, 52(8-9): 715-727.

30. Xiangyong Li, Zhiyong Cheng, Honglin Jin*. Dynamics of Ras complexes observed in living Cells. Sensors, 2012, 12(7): 9411-9422.

31. Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth K. Ng, Weiguo Cao, Lili Ding, Zhihong Zhang, Gang Zheng. Cytosolic delivery of LDL nanoparticle cargo using photochemical internalization. Photochemical & Photobiological Sciences. 2011, 10(5), 810-816. (Cover paper)

32. Honglin Jin, Jonathan F. Lovell, Juan Chen, Kenneth K. Ng, Weiguo Cao, Lili Ding, Zhihong Zhang, Gang Zheng. Investigating the specific uptake of EGF-conjugated nanoparticles in lung cancer cells using fluorescence imaging. Cancer nanotechnology (2010), 1(1): 71-78.


基金项目:

1. 国家自然科学优秀青年基金、820220402021/01-2023/12主持

2. 湖北省重点研发计划第二批(国际合作领域)2020BHB021主持

3. 国家自然科学基金面上项目、818742332019/01-2022/12主持

4. 国家自然科学基金青年项目、815030262016/01-2018/12主持

5. 湖北省自然科学基金面上项目、2019CFB4652019/01-2020/12主持

6. 吴阶平医学基金会专项基金、320.6750.183852018/06-2021/05主持

7. 2017年华中科技大学“学术新人”、人才启动经费、主持

8. 武汉协和医院院内基金、2016.03-2018.03主持

9. 华中科技大学青年教师基金、2015QN12015/01-2016/12主持

10. 生物靶向治疗研究湖北省重点实验室开放基金、2015-2017主持

11. 中国博士后科学基金特别资助、2013T607212013/06-2014/06主持

12. 中国博士后科学基金面上资助、2012M5214302012/06-2014/04主持


授权专利:

1. 一种抗肿瘤疫苗复合物及其制剂、制法及应用:金红林,杨坤禹,万超,孙亚洁,张玲玲。专利号ZL201910031298.5

2. 一种促进树突细胞摄取抗原肽的多肽、促进树突细胞摄取抗原肽的纳米颗粒及其应用:骆清铭、张智红、金红林、钱源。专利号ZL201410166872.5

3. 一种同时实现促进树突细胞迁移至淋巴结和多模式成像的方法:张智红、金红林、张宇、戴艳锋。专利号ZL201510788151.2

4. 一种可自组装成水凝胶的肿瘤杀伤性多肽及其应用:邹枕玮,金红林,陈静,伍钢,杨坤禹,胡建莉,彭纲,冯觉平,李品东,赵桂芳。专利号ZL201611105009.4


学术兼职:

担任亚太医学生物免疫学会肿瘤学分会首届委员会委员,湖北省医学生物免疫学学会老年病专委会副主任委员,湖北省医学生物免疫学学会转化医学专委会常务委员,以及湖北省临床肿瘤学会第一届肿瘤微环境专家委员会常务委员。基金委函评专家和湖北省重点项目评审专家,Journal of Nanobiotechnology客座编辑,Chinese Chemical Letters (CCL) Frontiers in Bioengineering and BiotechnologyFrontiers in Molecular Biosciences等期刊编委。Nano todayAdvanced Functional MaterialsACS nanoBiomaterialsTheranosticsCancer CommunicationsChinese Chemical LettersFrontiers in OncologyBioconjugate ChemistryFrontiers in Bioengineering and BiotechnologyAsian Journal of Pharmaceutical Sciences30余种期刊审稿人。


联系方式(邮箱):jin@mail.hzau.edu.cn


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